Resources

Clear writing on cognitive risk

Reviewed by clinicians in the network. Written for people making decisions, not for search engines.

Genetic Testing

Understanding Your APOE Results: What E4 Actually Means

One copy of APOE4 raises lifetime Alzheimer's risk roughly two to three fold — but roughly a quarter of the population carries it and most never develop the disease. Here is how to read a genotype report without either dismissing it or catastrophizing.

August 12, 20269 min read

Editor's note

Roughly one in four people carries at least one APOE4 allele, and most never develop Alzheimer's disease. The number is a probability, not a prognosis — and what you do with it matters more than the result itself.

Reviewed by Sarah Lindqvist, MS, CGC and Dr. Elena Marchetti, MD

Biomarkers

Plasma p-tau217 and the End of the Diagnostic Waiting Room

A blood test now approaches spinal-fluid accuracy for Alzheimer's pathology. We asked four network neurologists what that has changed in their clinics — and what it has not.

July 30, 20267 min read

Nutrition

The Ketogenic Diet Has an APOE4 Problem. Here's the Workaround.

Carriers frequently see sharp LDL and ApoB increases on standard high-saturated-fat protocols. Network dietitians walk through the unsaturated-fat-forward version and the monitoring cadence it requires.

July 8, 202611 min read

Precision Medicine

Eleven Medications in Nine Years: When the Problem Is Metabolism, Not Diagnosis

Ultrarapid and poor CYP2D6 metabolizers routinely accumulate long histories of failed psychiatric trials. A board-certified psychiatric pharmacist explains what a pharmacogenomic review can and cannot resolve.

June 21, 20268 min read

Getting Started

How to Build a Brain Health Team Without Spending $40,000

You do not need a longevity clinic membership to start. A sequencing guide for which professional to see first, what to test in year one, and where the money is genuinely well spent.

June 3, 202612 min read

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